A study suggests that there are common genetic pathways between alcohol consumption disorder and other dependencies, so that GWAS identifies affected genes as targets for new therapies could.
Researchers have shown that genetic factors play an important role in the differences in alcohol consumption between individuals and that heavy alcohol consumption is linked to the development of more than 60 diseases, including an increased risk of lung cancer. The team suggests that their results could be used to uncover drug targets for the condition.
A genome-wide association study (GWAS) of middle-aged white people in the UK identified six genes that may be associated with alcohol consumption. It also provides "insight into genes, pathways, and relationships for the risk of disease associated with high alcohol consumption," Dr. Andrew Thompson, Senior Research Associate, University of Liverpool, UK.
In order to better understand the role of genetics In alcohol consumption disorders, the team examined variations of single base pairs in DNA sequences for 502,000 people from the British biobank and repeated their results with data from Kaiser Permanents Genetic Epidemiology Research on adult health and to the age cohort.
All The genes tested showed significant changes in the worms' response to alcohol exposure. These genes have a real impact on the response to alcohol. "
Dr. Thompson told Drug Target Review: “We got used to model organisms (worm models). Test the functional effects of the genes identified in GWAS (ie what happens when the gene is removed). All genes tested showed significant changes in the worms' response to alcohol exposure. This is new in the field of alcohol and suggests that these genes have a real impact on the response to alcohol. “
The study published in Science Advances suggests that there may be a genetic link between:
Alcohol consumption and alcohol consumption A tendency to eat sugary foods because of the pathways involved in glucose metabolism and susceptibility to heavy alcohol consumption the risk of high alcohol consumption and the risk of gout and hypertensional alcohol consumption disorders as well as an increased risk of lung cancer.
In addition, Dr. Thompson: “When we examined the biological effects of the genes, we found evidence of several common pathways associated with different types of obsessive behavior and addiction, not just alcohol consumption. We are currently working on samples from patients with other dependencies to determine whether their genetic makeup resembles that of alcohol users. The aim is to investigate the hypothesis that the genes identified in this work are involved in common signaling pathways for different types of obsessive behavior / addiction.
"Taken together, this improved understanding of the molecular mechanisms that can contribute to heavy alcohol consumption will hopefully lead to the identification of goals that can be advanced for drug discovery or drug use conversion in the treatment of alcohol addiction or drug abuse broader substance use. "